List of articles (by subject)
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Open Access Article
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Fatemeh Rafiemanzelat -
Open Access Article
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Ehsan Alikhani -
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Zahra Talebpour Zeinab Zamani -
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Farzad Mehrjo -
Open Access Article
5 - Self-Assembly of Peptides and its Applications: A Review
Soheila EmamyariMolecular self-assembly is the spontaneous aggregation of molecules or macromolecules into supramolecular structures with non-covalent interactions. This phenomenon is an interdisciplinary research topic that has a lot of potential applications in various fields. One of MoreMolecular self-assembly is the spontaneous aggregation of molecules or macromolecules into supramolecular structures with non-covalent interactions. This phenomenon is an interdisciplinary research topic that has a lot of potential applications in various fields. One of the main driving forces of molecular self-assembly is the existence of molecular amphiphilicity in the system which can cause microphase separation and create complex and stable nanostructures. Self-assembling peptides are one of the most important classes of molecules with the ability to self-assemble. The rich self-assembly behavior is observed in systems of peptides, due to the simultaneous presence of different interactions (such as electrostatic interaction, hydrophobicity and hydrogen bond) in systems consisting of them and the diversity of their molecular configuration. Better understanding of peptides self-assembly enables the better design of peptides to form functional nanostructures. In this review article, at first, peptide self-assembly and its importance are stated. Then, some examples of self-assembling peptides which have attracted the interest of scientists for various reasons, such as cyclic peptides, amphiphilic peptides, ionic complementary peptides and some other examples, are explained. Also, some important applications and benefits of peptides self-assembly, which include nanoscale construction, tissue engineering, drug delivery, applications in biosensors, and the study of conformational diseases, are reviewed. Manuscript profile -
Open Access Article
6 - Mini-Review of Self-Healing Mechanism and Formulation Optimization of Polyurea Coating
Moein Behzadpour Mahdi Hemmatian DamghaniSelf-healing polymers are categorized as smart materials that are capable of surface protection and prevention of structural failure. Polyurethane/polyurea, as one of the representative coatings, has also attracted attention for industrial applications. Compared with po MoreSelf-healing polymers are categorized as smart materials that are capable of surface protection and prevention of structural failure. Polyurethane/polyurea, as one of the representative coatings, has also attracted attention for industrial applications. Compared with polyurethane, polyurea coating, with a similar formation process, provides higher tensile strength and requires shorter curing time. The working principle of polyurea self-healing mechanisms is to fill cracks by introducing more healing components, which can polymerize and seal damage in the material. Alternatively, it can also be addressed by encouraging continuous chemical reactions, which can form bonds to close gaps between the separated faces of material due to the damage. In this paper, extrinsic and intrinsic mechanisms are reviewed to address the efficiency of the self-healing process. Furthermore, the extrinsic and intrinsic mechanisms have been compared to attain a better understanding of the advantages and limitations of each mechanism. Moreover, formulation optimization and strategic improvement to ensure self-healing within a shorter period of time with acceptable recovery of mechanical strength are also discussed. The choice and ratio of diisocyanates, as well as the choice of chain extender, are believed to have a crucial effect on the acceleration of the self-healing process and enhance self-healing efficiency during the preparation of polyurea coatings. Manuscript profile -
Open Access Article
7 - A Review of Hydrogels Containing Fibers in Drug Delivery Systems
Mohammad Hossein Karami Majid Abdouss Mohammadreza Kalaee Omid MoradiHydrogels are three-dimensional networks of hydrophilic polymers capable of absorbing and retaining significant amounts of fluids, which are also widely applied in wound healing, cartilage tissue engineering, bone tissue engineering, release of proteins, growth factors, MoreHydrogels are three-dimensional networks of hydrophilic polymers capable of absorbing and retaining significant amounts of fluids, which are also widely applied in wound healing, cartilage tissue engineering, bone tissue engineering, release of proteins, growth factors, and antibiotics. In the past decades, a lot of research has been done to accelerate wound healing. Hydrogel-based scaffolds have been a recurring solution in both cases, although their mechanical stability remains a challenge, some of which have already reached the market. To overcome this limitation, the reinforcement of hydrogels with fibers has been investigated. The structural similarity of hydrogel fiber composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel formation techniques and fiber spinning methods has been very important in the development of scaffold systems with improved mechanical strength and medicinal properties. Hydrogel has the ability to absorb secretions and maintain moisture balance in the wound. In turn, the fibers follow the structure of the extracellular matrix (ECM). The combination of these two structures (fiber and hydrogel ) in a scaffold is expected to facilitate healing by creating a suitable environment by identifying and connecting cells with the moist and breathing space required for healthy tissue formation. Modifying the surface of fibers by physical and chemical methods improves the performance of hydrogel composites containing Manuscript profile -
Open Access Article
8 - A Review of Hydrogels Containing Fibers in Drug Delivery Systems
Mohammad Hossein Karami Majid Abdouss Mohammadreza Kalaee Omid MoradiHydrogels are three-dimensional networks of hydrophilic polymers capable of absorbing and retaining significant amounts of fluids, which are also widely applied in wound healing, cartilage tissue engineering, bone tissue engineering, release of proteins, growth factors, MoreHydrogels are three-dimensional networks of hydrophilic polymers capable of absorbing and retaining significant amounts of fluids, which are also widely applied in wound healing, cartilage tissue engineering, bone tissue engineering, release of proteins, growth factors, and antibiotics. In the past decades, a lot of research has been done to accelerate wound healing. Hydrogel-based scaffolds have been a recurring solution in both cases, although their mechanical stability remains a challenge, some of which have already reached the market. To overcome this limitation, the reinforcement of hydrogels with fibers has been investigated. The structural similarity of hydrogel fiber composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel formation techniques and fiber spinning methods has been very important in the development of scaffold systems with improved mechanical strength and medicinal properties. Hydrogel has the ability to absorb secretions and maintain moisture balance in the wound. In turn, the fibers follow the structure of the extracellular matrix (ECM). The combination of these two structures (fiber and hydrogel ) in a scaffold is expected to facilitate healing by creating a suitable environment by identifying and connecting cells with the moist and breathing space required for healthy tissue formation. Modifying the surface of fibers by physical and chemical methods improves the performance of hydrogel composites containing Manuscript profile -
Open Access Article
9 - Shape memory polymers: Structure, mechanism, functionality, and applications
Hamidreza Haydari Marziyeh HosseiniIn the last three decades, many researches have been conducted in the field of shape memory polymers, and in the past few years, the interest in research in this field has received a lot of attention. In this study, a comprehensive and complete review of the structure, MoreIn the last three decades, many researches have been conducted in the field of shape memory polymers, and in the past few years, the interest in research in this field has received a lot of attention. In this study, a comprehensive and complete review of the structure, mechanism, model and applications of this category of polymers has been done. In general, the mechanisms of shape memory polymers are divided into three groups: direct thermal induction, indirect thermal induction, and optical induction, and each has its own switch unit that controls the shape structure. These switches have amorphous and semi-crystalline phase, which are defined in two phase and molecular levels. Also, increasing the mechanical properties, including the strength and toughness of shape memory polymers, is of great importance, which can increase their efficiency. Shape memory polymers can be used in medical, aerospace, textile and other industries. In the textile industry, the electrospinning process is used as a simple and efficient method for the preparation of shape memory polymer fibers and the development of their structure, and the mechanism and method of preparation of these fibers will be investigated. In the last three decades, many researches have been conducted in the field of shape memory polymers, and in the past few years, the interest in research in this field has received a lot of attention. In this study, a comprehensive and complete review of the structure, mechanism, model and applications of this category of polymers has been done. Manuscript profile -
Open Access Article
10 - Investigating the Particle Size of Chitosan-Based Drug Carriers for the Release of 5-Fluorouracil Antitumor Drug
Mohammad Hossein Karami Majid Abdouss Mandana KaramiChitosan has been widely used as a natural biopolymer. The modification of chitosan for various applications can be easily achieved due to the abundant active groups (NH2 and OH) in the main chain. Controlled drug release makes the drug release rate predictable and repe MoreChitosan has been widely used as a natural biopolymer. The modification of chitosan for various applications can be easily achieved due to the abundant active groups (NH2 and OH) in the main chain. Controlled drug release makes the drug release rate predictable and repeatable for prolonged release drugs. Drug delivery systems prepared from nanoparticles show several advantages, including improved efficiency and reduced toxicity. Using drug delivery systems based on nanoparticles loaded with anti-cancer agents is an effective method for targeting cancer cells. These systems, with the ability to penetrate better inside the cells, combine the drug in a targeted way in the cells. Also, due to the enhanced permeability and retention (EPR), the possibility of better accumulation of drugs in the tumor site is provided. In most researches, the suitable particle size for the targeted release of drug nanocarriers has been reported to be less than 300 or 200 nm. This amount is suitable for the application of drug release for diffusion among tissues and causes the effect of increasing permeability. In this study, for the first time, it examines and analyzes the particle size and zeta potential (surface charge) of chitosan-based nanocarriers through dynamic light scattering and electron microscope tests in improving the release of the antitumor drug, 5-fluorouracil. Manuscript profile -
Open Access Article
11 - Investigating the Particle Size of Chitosan-Based Drug Carriers for the Release of 5-Fluorouracil Antitumor Drug
Mohammad Hossein Karami Majid Abdouss Mandana KaramiChitosan has been widely used as a natural biopolymer. The modification of chitosan for various applications can be easily achieved due to the abundant active groups (NH2 and OH) in the main chain. Controlled drug release makes the drug release rate predictable and repe MoreChitosan has been widely used as a natural biopolymer. The modification of chitosan for various applications can be easily achieved due to the abundant active groups (NH2 and OH) in the main chain. Controlled drug release makes the drug release rate predictable and repeatable for prolonged release drugs. Drug delivery systems prepared from nanoparticles show several advantages, including improved efficiency and reduced toxicity. Using drug delivery systems based on nanoparticles loaded with anti-cancer agents is an effective method for targeting cancer cells. These systems, with the ability to penetrate better inside the cells, combine the drug in a targeted way in the cells. Also, due to the enhanced permeability and retention (EPR), the possibility of better accumulation of drugs in the tumor site is provided. In most researches, the suitable particle size for the targeted release of drug nanocarriers has been reported to be less than 300 or 200 nm. This amount is suitable for the application of drug release for diffusion among tissues and causes the effect of increasing permeability. In this study, for the first time, it examines and analyzes the particle size and zeta potential (surface charge) of chitosan-based nanocarriers through dynamic light scattering and electron microscope tests in improving the release of the antitumor drug, 5-fluorouracil. Manuscript profile