Self-Assembly of Peptides and its Applications: A Review
Subject Areas :
Soheila
Emamyari
1
(Institute for Advanced Studies in Basic Sciences (IASBS))
Keywords: molecular self-assembly, peptide, polymer, microphase separation, nanostructure,
Abstract :
Molecular self-assembly is the spontaneous aggregation of molecules or macromolecules into supramolecular structures with non-covalent interactions. This phenomenon is an interdisciplinary research topic that has a lot of potential applications in various fields. One of the main driving forces of molecular self-assembly is the existence of molecular amphiphilicity in the system which can cause microphase separation and create complex and stable nanostructures. Self-assembling peptides are one of the most important classes of molecules with the ability to self-assemble. The rich self-assembly behavior is observed in systems of peptides, due to the simultaneous presence of different interactions (such as electrostatic interaction, hydrophobicity and hydrogen bond) in systems consisting of them and the diversity of their molecular configuration. Better understanding of peptides self-assembly enables the better design of peptides to form functional nanostructures. In this review article, at first, peptide self-assembly and its importance are stated. Then, some examples of self-assembling peptides which have attracted the interest of scientists for various reasons, such as cyclic peptides, amphiphilic peptides, ionic complementary peptides and some other examples, are explained. Also, some important applications and benefits of peptides self-assembly, which include nanoscale construction, tissue engineering, drug delivery, applications in biosensors, and the study of conformational diseases, are reviewed.
1. 1. Boncheva M., Whitesides G. M., Making Things by Self-Assembly, MRS Bull., 30, 736-742, 2005.
2. Jones R. A. L., Soft Condensed Matter, Oxford University Press, Oxford, First ed., 2002.
3. Jing H., Wang Y., Desai P. R., Ramamurthi K. S., Das S., Lipid Flip-Flop and Desorption from Supported Lipid Bilayers is Independent of Curvature, PLoS ONE, 15, e0244460, 2020.
4. Rathore S. S., Liu Y., Yu H., Wan C., Lee M., Yin Q., Stowell M. H. B., Shen J., Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE, Cell Rep., 29, 4583-4592.e3, 2019.
5. Peyret A., Zhao H., Lecommandoux S., Preparation and Properties of Asymmetric Synthetic Membranes Based on Lipid and Polymer Self-Assembly, Langmuir, 34, 3376-3385, 2018.
6. McManus J. J., Charbonneau P., Zaccarelli E., Asherie N., The Physics of Protein Self-Assembly, Curr. Opin. Colloid Interface Sci., 22, 73-79, 2016.
7. Gui H., Guan G., Zhang T., Guo Q., Microphase-Separated, Hierarchical Macroporous Polyurethane from a Nonaqueous Emulsion-Templated Reactive Block Copolymer, Chem. Eng. J., 365, 369-377, 2019.
8. Glagolev M. K., Glagoleva A. A., Vasilevskaya V. V., Microphase Separation in Helix-Coil Block Copolymer Melts: Computer Simulation, Soft Matter, 17, 8331-8342, 2021.
9. Tornesello A. L., Borrelli A., Buonaguro L., Buonaguro F. M., Tornesello M. L., Antimicrobial Peptides as Anticancer Agents: Functional Properties and Biological Activities, Molecules, 25, 2850, 2020.
10. Ghadiri M. R., Granja J. R., Milligan R. A., McRee D. E., Khazanovich N., Self-Assembling Organic Nanotubes Based on a Cyclic Peptide Architecture, Nature, 366, 324-327, 1993.
11. Hu K., Xiong W., Sun C., Wang C., Li J., Yin F., Jiang Y., Zhang M.-R., Li Z., Wang X., Li Z., Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size, CCS Chem., 2, 42-51, 2020.
12. Jian H., Wang M., Dong Q., Li J., Wang A., Li X., Ren P., Bai S., Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting, ACS Appl. Mater. Interfaces, 11, 46419-46426, 2019.
13. Hartgerink J. D., Beniash E., Stupp S. I., Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers, Science, 294, 1684-1688, 2001.
14. Sun L., Zheng C., Webster T. J., Self-Assembled Peptide Nanomaterials for Biomedical Applications: Promises and Pitfalls, Int. J. Nanomedicine., 12, 73-86, 2017.
15. Vauthey S., Santoso S., Gong H., Watson N., Zhang S., Molecular Self-Assembly of Surfactant-Like Peptides to Form Nanotubes and Nanovesicles, Proc. Natl. Acad. Sci. USA, 99, 5355-5360, 2002.
16. Rodrigo E., Walter M., Reza M., Castelletto V., Ruokolainen J., Connon C., Alves W., Hamley I., Self-Assembled Arginine-Capped Peptide Bolaamphiphile Nanosheets for Cell Culture and Controlled Wettability Surfaces, Biomacromolecules, 16, 3180-3190, 2015.
17. Jun S., Hong Y., Imamura H., Ha B. Y., Bechhoefer J., Chen P., Self-Assembly of the Ionic Peptide EAK16: The Effect of Charge Distributions on Self-Assembly, Biophys. J., 87, 1249-1259, 2004.
18. Wu F., Fu D., Self-Assembling Peptide as a Carrier for Hydrophobic Anticancer Drug Combretastatin A4-Characterization and In Vitro Delivery, J. Comput. Theor. Nanosci., 13, 2334-2339, 2016.
19. Emamyari S., Fazli H., All-Atom Molecular Dynamics Study of EAK16 Peptide: The Effect of pH on Single-Chain Conformation, Dimerization and Self-Assembly Behavior, Eur. Biophys. J., 43, 143-155, 2014.
20. Emamyari S., Fazli H., pH-Dependent Self-Assembly of EAK16 Peptides in the Presence of a Hydrophobic Surface: Coarse-Grained Molecular Dynamics Simulation, Soft Matter, 10, 4248-4257, 2014.
21. Li B., You N., Liang Y., Zhang Q., Zhang W., Chen M., Pang X., Organic Templates for Inorganic Nanocrystal Growth, Energy Environ. Mater., 2, 38-54, 2019.
22. Wang C.-C., Wei S.-C., Luo S.-C., Recent Advances and Biomedical Applications of Peptide-Integrated Conducting Polymers, ACS Appl. Bio Mater., 5, 1916-1933, 2022.
23. Reches, M., Gazit E., Casting Metal Nanowires within Discrete Self-Assembled Peptide Nanotubes, Science, 300, 625-627, 2003.
24. Gelain F., Luo Z., Zhang S., Self-Assembling Peptide EAK16 and RADA16 Nanofiber Scaffold Hydrogel, Chem. Rev., 120, 13434-13460, 2020.
25. Gelain F., Luo Z., Rioult M., Zhang S., Self-assembling Peptide Scaffolds in the Clinic, NPJ Regen. Med., 6, 9, 2021.
26. Kisiday J., Jin M., Kurz B., Hung H., Semino C., Zhang S., Grodzinsky A. J., Self-Assembling Peptide Hydrogel Fosters Chondrocyte Extracellular Matrix Production and Cell Division: Implications for Cartilage Tissue Repair, Proc. Natl. Acad. Sci. USA, 99, 9996-10001, 2002.
27. Hudalla G. H., Murphy W. L. Mimicking the Extracellular Matrix: The Intersection of Matrix Biology and Biomaterials, Royal Society of Chemistry, Cambridge, UK, 2016.
28. Keyes-Baig C., Duhamel J., Fung S., Bezaire J., Chen P., Self-Assembling Peptide as a Potential Carrier of Hydrophobic Compounds, J. Am. Chem. Soc., 126, 7522-7532, 2004.
29. Yemini M., Reches M., Rishpon J., Gazit E., Novel Electrochemical Biosensing Platform Using Self-Assembled Peptide Nanotubes, Nano Lett., 5, 183-186, 2005.
30. Tublin J. M., Adelstein J. M., Monte F. d., Combs C. K., Wold L. E., Getting to the Heart of Alzheimer Disease, Circ. Res., 124,142-149, 2019.