Review on the Polysulfone Based Membranes for Separation of Low-Density Lipoprotein from Blood
Subject Areas :Rahim Dehghan 1 * , Jalal Barzin 2 , Behnam Darabi 3 , Hamidreza Ghaderi 4
1 - Biomaterial department, Iran Polymer and Petrochemical Institute
2 - 1. Biomaterials department, Iran polymer and petrochemical institute (IPPI), Tehran, Iran. P. O. Box:14975-112
3 - 3. School of Paramedical Sciences, Shiraz University of Medical Science, Shiraz, Iran
4 - 4. School of Advanced Technologies in Medicine, Departement of Tissue engineering, Fasa University of medical science, Fasa, Iran.
Keywords: membrane, blood, low-density lipoprotein, filtration, adsorption,
Abstract :
Cardiovascular diseases are the most common cause of fatality all over the world. A severe increase of low-density lipoprotein (LDL) concentration in blood is recognized as the main cause of coronary artery disease (CAD) and atherosclerosis. LDL apheresis from blood is one of the extracorporeal options for patients suffering from this disorder which drug therapy is not effective for them. LDL apheresis is classified in cascade filtration and adsorption-based methods. In this study further reviewing all LDL apheresis techniques, polysulfone (PSU) membranes for selective adsorption of LDL were investigated. By inspiring from inherent LDL receptor (LDLR) of body, different methods including heparinization of PSU membrane by various methods such as chloromethylation, treatment with ammonia plasma and co-deposition of polydopamine and polyethyleneimine can be used for adsorption of LDL from the blood. Also, membrane ionic glycosylation by click chemistry and grafting of alginate sulfate on the surface of PSU membrane to adsorption of LDL were reviewed. To investigate surface modification accuracy, different analyses such as X-ray photo spectroscopy (XPS), Attenuated total reflectance Fourier transform infrared (ATR-FTIR), -Potential and water contact angle are used. Blood compatibility is another factor for the development of these membranes for defined application.
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