بررسی خواص و کاربرد انواع چسبهای مورد استفاده در بدن
محورهای موضوعی : زیست پلاستیک ها و پلیمرهای تجديد پذیرحمیدرضا حیدری 1 , مرضیه حسینی 2
1 - دانشگاه صنعتی امیرکبیر
2 - پژوهشگاه پلیمر و پتروشیمی ایران
کلید واژه: چسب استخوان, پلیمر, چسبندگی بافت, زیستتخریبپذیر,
چکیده مقاله :
امروزه بهمنظور درمان و ترمیم شکستگیهای استخوان، از پیچ و پلاکهای فلزی استفاده میشود؛ اما بهطور معمول این روش مشکلاتی در جراحیها و شکستگیهای استخوان از جمله شکستگیهای جمجمه و ستون مهرهها به دنبال خواهد داشت که بهعنوان مثال میتوان به مواردی همچون زمان اعمال طولانی که سبب افزایش زمان جراحی میشود، احتمال آسیب به بافتهای استخوانی اطراف شکستگی، دشواری و شکست پلاکها اشاره کرد. از این رو پژوهشگران و جراحان ارتوپد، بهدنبال جایگزینی مناسب برای این روش هستند. استفاده از چسبهای استخوان یکی از فناوریهای جدید در این راستا است که برای حل چنین مشکلاتی پیشنهاد شده است. این چسبها باید دارای ویژگیهایی همچون چسبندگی قابلقبول پروتئینها، بافتها و استخوان بهویژه در حضور چربی اطراف استخوان و پایداری چسبندگی در این محیطها باشند و با گذشت زمان، استحکام مکانیکی بالایی در برابر تنشهای کششی، برشی و فشاری داشته باشند. همچنین داشتن خصوصیاتی از جمله غیرسمی، زیستسازگاری، زیستتخریبپذیری مناسب، اعمال سریع و آسان و تثبیت خوب شکستگی برای این چسبها الزامی است. در این مقاله به برخی از این چسبهای زیستی، نحوهی تهیه و کاربرد آنها پرداخته شده است.
Nowadays, in order to treat and repair bone fractures, metal screws and plates are used; But normally, this method will cause problems in surgeries and bone fractures, including skull and vertebral column fractures, which for example can include things such as long operation time which increases the surgery time, the possibility of damage to the bone tissues around the fracture, difficulty and failure. He pointed out the plates. Therefore, researchers and orthopedic surgeons are looking for a suitable alternative to this method. The use of bone glues is one of the new technologies in this direction that has been proposed to solve such problems. These adhesives must have characteristics such as acceptable adhesion of proteins, tissues and bone, especially in the presence of fat around the bone and stability of adhesion in these environments, and over time, have high mechanical strength against tensile, shear and compressive stresses. Also, having characteristics such as non-toxicity, biocompatibility, appropriate biodegradability, quick and easy application, and good fracture stabilization are required for these adhesives. In this article, some of these bio-adhesives, how to prepare and use them are discussed. Nowadays, in order to treat and repair bone fractures, metal screws and plates are used; But normally, this method will cause problems in surgeries and bone fractures, including skull and vertebral column fractures, which for example can include things such as long operation time which increases the surgery time, the possibility of damage to the bone tissues around the fracture, difficulty and failure.
1. Adams D., Adhesive Bonding: Science, Technology and Applications, Woodhead Publishing, 2nd Edition, 2021.
2. Pocius A.V., Adhesion and Adhesives Technology: An Introduction, Carl Hanser Verlag GmbH Co KG, 2nd Edition, 2021.
3- Mazza P. P., Martini P., Sala B., A New Palaeolithic Discovery: Tar-hafted Stone Tools in a Europea Mid-pleistocene Bone-bearing Bed, Journal of Archaeological Science, 33, 1310-1318, 2006.
4. Kozowyk P.R.B., Soressi M., Pomstra D., Langejans G.H.J., Experimental Methods for the Palaeolithic Dry Distillation of Birch Bark: Implications for the Origin and Development of Neandertal Adhesive Technology, Scientific Reports., 7, 2045-2322, 2017.
5. Pocius A.V., Adhesion and Adhesives Technology, Polymer Int., 53, 1391-1396, 2004.
6. Ali A., Rehman K., Majeed H., Khalid M.F., Akash M.S.H. Polysaccharide-based Adhesives, Green Adhesives: Preparation, In book: Properties and Applications, Wiley,165-180, 2020.
7. Donkervolcke M.F., Burny D., Muster, Tissues and Bone Adhesives: Historical Aspects, Biomaterials, 19, 1461-1466, 1998.
8. Thirunavukkarasu N.K., Dhinamala R., Moses Inbaraj, Production of Chitin from Two Marine Stomatopods Oratosquilla spp. (Crustacea), J. Chem. Pharm. Res., 3, 353-359, 2011.
9. Pradip K.D., Joydeep D.V.S., Chitin T., Chitosan, Chemistry, Properties & Applications, Journal of Scientific & Industrial Research., 63, 20-31, 2004.
10. Majeti N.V., Kumar R., A Review of Chitin and Chitosan Applications, Reactive & Functional Polymers, 46, 1–27, 2000.
11. Nejati Hafdani F., Sadeghinia N., A Review on Application of Chitosan as a Natural Antimicrobial, World Academy of
Science., 74, 257-261, 2011.
12. Mati-Baouche N., Elchinger P.H., Baynast H.D., Pierre G., Delattre C., Michaud P., Chitosan as an Adhesive, European Polymer Journal., 60, 198-212, 2014.
13. Heiss V., Kraus R., Schluckebier D., Stiller A.C., Wenisch S., Schnettler R., Bone Adhesives in Trauma and Orthopedic Surgery, European Journal of Trauma., 32, 141-148, 2006.
14. No H.K., Meyers S.P., Preparation and Characterization of Chitin and Chitosan (A Review), J. Aquatic Food product Technol., 4, 27-52, 1995.
15. Gossen M.F.A., Applications of Chitin and Chitosan, Technomic Publishing Company Book, Lancaster, 503-509, 1997.
16. Roberts G.A.F., Thirty Years of Progress in Chitin and
Chitosan, Progress on Chemistry and Application of Chitin and Its Derivatives, 13, 7-15, 2008.
17. Gleghorn J.P., Christopher S.D., Cabodi M., Stroock A.D., Bonassar L.J., Adhesive Properties of Laminated Alginate Gels for Tissue Engineering of Layered Structures, Journal of Biomedical Materials Research Part A., 85, 611-618, 2008.
18. Berg A., Peters F., Schnabelrauch M., Biodegradable Methacrylate-based Adhesives for Surgical Applications, Biological Adhesive Systems., 65, 261-272, 2010.
19. Hoffmann B., Volkmer E., Kokott A., Augat P., Ohnmacht M., Sedlmayr N., Skchier M., Characterisation of a New Bioadhesive System Based on Polysaccharides with the Potential to be Used as Bone Glue, Journal of Materials Science: Materials in Medicine, 20, 2001-2009, 2009.
20. Ortiz A.D.C., Fideles S.O.M., Pomini K.T., Reis C.H.B., Bueno C.R.D.S., Pereira E.D.S.B.M., Rossi, J.D.O., Novais P.C., Pilon J.P.G., Rosa Junior G.M., Buchaim D.V., Effects of Therapy with Fibrin Glue Combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic Review, Cells, 10, 2323, 2021.
21. Balcioglu S., Gurses C., Imren Ozcan I., Yildiz A., Koytepe S., Parlakpinar H, Vardi N., Ates B., Photocrosslinkable
Gelatin/collagen Based Bioinspired Polyurethane-acrylate bone Adhesives with Biocompatibility and Biodegradability,
International Journal of Biological Macromolecules, 192, 1344-1356, 2021.
22. Liu Y., Sai C.N., Jiashing Y., Tsai W.B., Modification and Crosslinking of Gelatin-based Biomaterials as Tissue Adhesives,
Colloids and Surfaces B: Biointerfaces, 174, 316-323, 2019.
23. Haider S., Park S.H., Preparation, Swelling and Electro-
mechano-chemical Behaviors of a Gelatin–chitosan Blend Membrane, Soft Matter., 4, 485-492, 2008.
24. Lia Y.J., Barth_Es-Biesela D., Salsac A.V., Polymerization Kinetics of N-butyl Cyanoacrylate Glues Used for Vascular Embolization, Journal of the Mechanical Behavior of Biomedical Materialsjanuary., 12, 1-29, 2017.
25. Langlois J., AL E.T., The Use of 2-octylcyanoacrylate (Dermabond®) for the Treatment of Nail Bed Injuries in Children:
Results of a Prospective Series of 30 Patients, Journal of Children's Orthopaedics, 4, 61-65, 2010.
26. Ninan L,. Monahan J., Stroshine R.L., Wilker J.J., Shi R., Adhesive Strength of Marine Mussel Extracts on Porcine Skin, Biomaterials, 24, 4091-4099, 2003.
27. Pizzi A., Mittal K.L., Handbook of Adhesives Technology, Marcel Dekker, Inc, CRC Press, New York, 681-695, 2003.
28. Leggat P.A., Smith D. R., Kedjarune V., Surgical Applications of Cyanoacrylate Adhesives: A Review of Toxicity, ANZ Journal of Surgery, 77, 209-213, 2007.
29. Lee B.P., Huang K., Nunalee F.N., Shull K.R., Messersmith P.B., Synthesis of 3,4dihydroxyphenylalanine (DOPA) Containing
Monomers and Their Co-Polymerization with PEG-diacrylate to form Hydrogels, J Biomater Sci Polym Ed., 15, 449-464, 2004.
30. Chis A.A., Dobrea C., Morgovan C., Arseniu A.M., Rus L.L., Butuca A., Juncan A.M., Totan M., Vonica-Tincu A.L., Cormos G. and Muntean A.C., Applications and Limitations of Dendrimers in Biomedicine, Molecules, 25, 3982, 2020.
31. Haofang Z., Xu G., He Y., Mao H., Kong D., Luo K., Tang W., Liu R., Gu Z., A Dual-Bioinspired Tissue Adhesive Based on Peptide Dendrimer with Fast and Strong Wet Adhesion,
Advanced Healthcare Materials, 11, 2200874, 2022.
32. Golling F.E., Polyurethanes for Coatings and Adhesives Chemistry and Applications, Polymer International, 68, 848-855, 2019.
33. Rahman M.M., Kim H.D., Characterization of Waterborne Polyurethane Adhesives Containing Different Soft Segments, Journal of Adhesion Science and Technology, 21, 81-96, 2007.
34. Fletcher R.L., Callow M.E., The Settlement, Attachment and Establishment of Marine Algal Spores, British Phycological
Journal, 27, 303-329, 1992.
35. Potin P., Leblanc C., Phenolic-based Adhesives of Marine Brown Algae, Biological Adhesives., 42, 105-124, 2006.
36. Yamada H., Guo Y., Matsumoto T., Effects of A Pectic Polysaccharide from a Medicinal Herb, the Roots of Bupleurum
Falcatum l. On Interleukin 6 Production of Murine b Cells and b Cell Lines, Immunopharmacology., 49, 307-316, 2000.
37. Sun W., Neuzil P., Kustandi T.S., The Nature of the Gecko Lizard Adhesive Force, Biophysical Journal, 89, 14-17, 2005.
38. Graham L.D., Glattauer V., Huson M. G., Characterization of a Protein-based Adhesive Elastomer Secreted by the Australian Frog Notaden Bennetti, Biomacromolecules, 6, 3300–3312, 2005.
39. Lee H., Lee B.P., Messersmith P.B., A Reversible Wet/dry Adhesive Inspired by Mussels and Geckos, Nature, 448, 338-341, 2007.
40. Shahbazi S., Moztarzade F., Mir Mohamad Sadeghi G.,
Jafari Y., In Vitro Study of a New Biodegradable Nanocomposite
Based on Polypropylene Fumarate as Bone Glue, Materials Science and Engineering., 69,1201-1209, 2016.
41. Shao H., A Water-borne Adhesive for Bone Repair Modeled
After Sandcastle Worm Adhesive, Biomacromolecules, 72, 124-131, 2010.
42. Duarte A.P, Coelho J.F., Bordado J.C., Cidade M.T., Gil M.H., Surgical adhesives: Systematic Review of the Main Types
and Development Forecast, Progress in Polymer Science, 37,1031-1050, 2012.