مروری بر روش های ساخت نانوکامپوزیت بر پایه کیتوسان در دارورسانی
محورهای موضوعی :
1 - فناوری های نوین
کلید واژه: دارورسانی کیتوسان نانوذرات نانوکامپوزیت روش های سنتز,
چکیده مقاله :
سامانه‌های دارورسانی، فناوری انتقال هدفمند یا کنترل انتشار عوامل درمانی هستند. توسعه حامل مناسب دارو در کاربردهای زیست پزشکی به دلیل کاهش اثرات مضر جانبی ناخواسته و بهبود اثرات درمانی سودمند هستند. نانوذرات به عنوان حامل دارو به دلیل توانایی حمل انواع دارو به قسمت‌های متفاوت بدن در زمان مناسب بسیار با اهمیت هستند. کیتوسان پلیمری زیست تخریب پذیر، زیست سازگار و زیست چسبنده است که توجه زیادی را در دارورسانی به خود جلب کرده است. سامانه‌های دارورسانی تهیه شده از نانوذرات، مزایای متعددی از جمله بهبود کارایی و کاهش سمیت از خود نشان می‌دهند. نانوذرات کیتوسان، با توجه به اندازه کوچک و نسبت سطح به حجم بزرگی که دارند خواص فیزیکی-شیمیایی، ضدباکتری و زیستی بهتری نسبت به حالت توده متناظر را دارند. نانوکامپوزیت‌های بر پایه کیتوسان به عنوان حامل دارورسانی بسیار مورد توجه قرار گرفته اند؛ زیرا خواص مناسب بهتری نسبت به پلیمر خالص ارائه می‌دهند.
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1. Bajaj M., Winter J., and Gallert C., Effect of Deproteination and Deacetylation Conditions on Viscosity of Chitin and Chitosan Extracted from Crangon Crangon Shrimp Waste, Biochemical Engineering Journal, 56, 51-62, 2011.
2. Bernkop-Schnürch A., and Dünnhaupt S., Chitosan-based Drug Delivery Systems, European Journal of Pharmaceutics and Biopharmaceutics, 81, 463-469, 2012.
3. Vaghari H., Jafarizadeh-Malmiri H., Berenjian A., and Anarjan, N., Recent Advances in Application of Chitosan in Fuel Cells, Sustainable Chemical Processes, 1, 16, 2013.
4. Pillai C. K. S., Paul W., and Sharma C. P., Chitin and Chitosan Polymers: Chemistry, Solubility and Fiber Formation, Progress in Polymer Science, 34, 641-678, 2009.
5. Prabaharan M ,. Chitosan Derivatives as Promising Materials for Controlled Drug Delivery, Journal of Biomaterials Applications, 23, 5-36, 2008.
6. Al Sagheer F. A., Al-Sughayer M. A., Muslim S., and Elsabee M. Z., Extraction and Characterization of Chitin and Chitosan from Marine Sources in Arabian Gulf, Carbohydrate Polymers, 77, 410-419, 2009.
7. Ohya Y., Shiratani M., Kobayashi H., and Ouchi T., Release Behavior of 5-fluorouracil from Chitosan-gel Nanospheres Immobilizing 5-fluorouracil Coated with Polysaccharides and their Cell Specific Cytotoxicity, Journal of Macromolecular Science—Pure and Applied Chemistry , 31, 629-642, 1994.
8. Wang J. J., Zeng Z. W., Xiao R. Z., Xie T., Zhou G. L., Zhan X. R., and Wang S. L., Recent Advances of Chitosan Nanoparticles as Drug Carriers, International Journal of Nanomedicine, 6, 765, 2011.
9. Agnihotri S. A., Mallikarjuna N. N., and Aminabhavi T. M., Recent Advances on Chitosan-based Micro-and Nanoparticles in Drug Delivery, Journal of Controlled Release, 100, 5-28, 2004.
10. Grenha A., Chitosan Nanoparticles: a Survey of Preparation Methods, Journal of drug targeting, 20, 291-300, 2012.
11. Berthold A., Cremer K., and Kreuter J. S. T. P., Preparation and Characterization of Chitosan Microspheres as Drug Carrier for Prednisolone Sodium Phosphate as Model for Anti-inflammatory Drugs, Journal of Controlled Release , 39, 17-25, 1996.
12. Estevinho B. N., Rocha F., Santos L., and Alves A., Microencapsulation with Chitosan by Spray Drying for Industry Applications–A review, Trends in Food Science & Technology, 31, 138-155, 2013.
13. Mitra S., Gaur U., Ghosh P. C., and Maitra A. N., Tumour Targeted Delivery of Encapsulated Dextran–Doxorubicin Conjugate Using Chitosan Nanoparticles as Carrier, Journal of Controlled Release, 74, 317-323, 2001.
14. Calvo P., Remunan‐Lopez C., Vila‐Jato J. L., and Alonso M. J., Novel Hydrophilic Chitosan‐Polyethylene Oxide Nanoparticles as Protein Carriers, Journal of Applied Polymer Science, 63, 125-132, 1997.
15. Anandhakumar S., Krishnamoorthy G., Ramkumar K. M., and Raichur A. M., Preparation of Collagen Peptide Functionalized Chitosan Nanoparticles by Ionic Gelation Method: An Effective Carrier System for Encapsulation and Release of Doxorubicin for Cancer Drug Delivery, Materials Science and Engineering: C, 378-385, 2017.
16. Xu J. H., Li S. W., Tostado C., Lan W. J., and Luo G. S., Preparation of Monodispersed Chitosan Microspheres and in Situ Encapsulation of BSA in a co-axial Microfluidic Device, Biomedical Microdevices, 11, 243-249, 2009.
17. Xu J., Xu X., Zhao H., and Luo G., Microfluidic Preparation of Chitosan Microspheres with Enhanced Adsorption Performance of Copper (II), Sensors and Actuators B: Chemical, 183, 201-210, 2013.
18. Yang C. H., Huang K. S., Lin P. W., and Lin Y. C. Using a Cross-flow Microfluidic Chip and External Crosslinking Reaction for Monodisperse TPP-Chitosan Microparticles. Sensors and Actuators B: Chemical, 124, 510-516, 2007.
19. Xu J. H., Zhao H., Lan W. J., and Luo G. S. A novel Microfluidic Approach for Monodispersed Chitosan Microspheres with Controllable Structures, Advanced Healthcare Materials, 1, 106-111, 2012.
20. Widder K. J., Senyei A. E., and Scarpelli D. G., Magnetic Microspheres: A Model System for Site Specific Drug Delivery in Vivo, Proceedings of the Society for Experimental Biology and Medicine, 158, 141-146, 1978.
21. Elmizadeh H., Khanmohammadi M., Ghasemi K., Hassanzadeh G., Nassiri-Asl, M., and Garmarudi A. B., Preparation and Optimization of Chitosan Nanoparticles and Magnetic Chitosan Nanoparticles as Delivery Systems Using Box–Behnken Statistical Design, Journal of Pharmaceutical and Biomedical Analysis, 80, 141-146, 2013.
22. Reddy D. H. K., and Lee S. M., Application of Magnetic Chitosan Composites for the Removal of Toxic Metal and Dyes from Aqueous Solutions, Advances in Colloid and Interface Science, 201, 68-93, 2013.
23. Karimi Z., Abbasi S., Shokrollahi H., Yousefi G., Fahham M., Karimi L., and Firuzi O., Pegylated and Amphiphilic Chitosan Coated Manganese Ferrite Nanoparticles for pH-sensitive Delivery of Methotrexate: Synthesis and Characterization, Materials Science and Engineering: C, 71, 504-511, 2017.
24. Montha W., Maneeprakorn W., Buatong N., Tang I. M., and Pon-On W., Synthesis of Doxorubicin-PLGA Loaded Chitosan Stabilized (Mn, Zn) Fe2O4 Nanoparticles: Biological Activity and pH-Responsive Drug Release, Materials Science and Engineering: C, 59, 235-240, 2016.
25. Huang H., Yuan Q., and Yang X., Preparation and Characterization of Metal–Chitosan Nanocomposites, Colloids and surfaces B: Biointerfaces, 39, 31-37, 2004.
26. Yadollahi M., Farhoudian S., and Namazi H., One-pot Synthesis of Antibacterial Chitosan/Silver Bio-Nanocomposite Hydrogel Beads as Drug Delivery systems, International Journal of Biological Macromolecules, 79, 37-43, 2015.
27. Kumari S., and Singh R. P., Glycolic Acid-g-Chitosan-Gold Nanoflower Nanocomposite Scaffolds for Drug Delivery and Tissue Engineering, International journal of Biological Macromolecules, 50, 878-883, 2012.
28. Pramanik A., Laha D., Dash S. K., Chattopadhyay S., Roy S., Das D. K., ... and Karmakar P., An in-vivo Study for Targeted Delivery of Copper-Organic Complex to Breast Cancer Using Chitosan Polymer Nanoparticles, Materials Science and Engineering: C, 68, 327-337, 2016.
29. Zhang H., Yan T., Xu S., Feng S., Huang D., Fujita M., and Gao X. D., Graphene Oxide-Chitosan Nanocomposites for Intracellular Delivery of Immunostimulatory CpG Oligodeoxynucleotides, Materials Science and Engineering: C, 73, 144-151, 2017.
30. Singh R. P., Sharma G., Singh S., Bharti S., Pandey B. L., Koch B., and Muthu M. S., Chitosan-Folate Decorated Carbon Nanotubes for Site Specific Lung Cancer Delivery, Materials Science and Engineering: C, 77, 446-458, 2017.